From molecules to human data.

From ideas to real products.

We are the strategic partner for pharmaceutical companies and innovative teams, helping transform ideas into finished products. Efficiently. We combine industrial expertise with complete development capabilities, from API and formulation to preclinical and clinical stages. One platform, one contract. What’s yours, stays yours.

Do any of these situations sound familiar?

Scientific teams & startups

Got a brilliant idea or molecule, but lack the industrial experience to push it all the way to a finished product?

Worried that partnering with a “big player” means losing your IP or product control?

Need to validate your business case and prep for investor questions you don't yet have the answers to?

We provide the missing development and industrial know-how, manage the entire process under a single NDA, and your IP stays 100% yours.

API manufacturers

Getting crushed by cheaper competition? Looking for a way to give your API undeniable added value?

Want to show customers your substance isn't just a "powder", but a stable, functional base for future medicine?

Hitting a wall with a complex patent situation or challenging physicochemical properties of APIs?

We help you prove that your API is perfectly suited for dosage form development, ensuring that price isn't the only reason a customer chooses you.

Drug product developers

Handling high-risk projects or innovative dosage forms that stretch your internal capacity to the limit?

In a race against time and need a partner who can manage parallel processes without unnecessary red tape?

Lack a direct link between API development and the final dosage form, impeding your project's momentum?

We provide the missing expertise and capacity, perform testing including in vivo models, and de-risk your most critical projects.

Established pharmaceutical companies

Looking for additional capacity for your ongoing projects?

Need to quickly verify a new API or excipient supplier and manufacture test batches in small scale?

In need of rapid manufacturing troubleshooting for an established product or a complex technology transfer?

We are a flexible team of industrial experts with hands-on industrial experience, solving your challenges without delay.

Services

We support all parts of your project.

We help you assess your project, provide a first estimate of technical feasibility, prepare a business case, perform an FTO patent analysis, and propose next steps based on a GAP analysis.

We develop and optimise synthetic routes and select optimal crystallisation conditions to obtain the most suitable solid form of the API for further development and testing. Our capabilities cover a broad range of solid-state development approaches, including polymorphs, salts, cocrystals, and amorphous systems, as well as stabilization strategies using polymers or amino acids. Concomitantly with analytical method development, we support process transfer and scale-up to pilot or manufacturing scale. If required, selected form(s) in GMP quality for clinical studies can be supplied or assistance with technology transfer to the client or manufacturing partner.

For innovative projects, we support both the design and synthesis of prodrugs to improve key drug properties such as solubility, bioavailability, stability, or pharmacokinetic performance. The development of prodrug candidates is accompanied by IP landscape and FTO assessments, patent strategy and patent application preparation, as well as preclinical, clinical, and toxicological evaluation.

In parallel with solid form screening, we perform comprehensive reverse engineering of the reference product. We apply unique in-house analytical methodologies to estimate API particle size within the dosage form, determine the quantitative composition of the drug product, assess chemical and solid-state degradation pathways, and identify the disintegration mechanism and critical attributes governing API release from formulation under various conditions.

We perform solid form pre-selection by comparing the reference API form with newly designed forms, evaluating chemical stability, solid-state stability, and advanced in vitro performance using insights obtained from reverse engineering of the reference product.

Pre-selected solid forms are subsequently formulated into prototype drug products on small-scale industrial equipment. Such prototypes are designed to minimise the impact of different physicochemical properties of the new API form or supplier on the overall drug product performance, and reduce technical risks.

The developed formulations are subsequently evaluated in comparative in vivo studies using the most appropriate animal model. The model is selected based on the dosage form type, indication, route of administration, toxicological considerations, specific study objectives and future human studies. At this stage, a complete clinical development strategy is outlined and an LC–MS analytical endpoint is established.

The development follows a rapid and flexible iterative cycle, enabling the efficient optimisation of both the API form and the drug product:  API form design → DP preparation → in vivo testing → optimisation → API/DP refinement → confirmatory study, until comparable pharmacokinetic or pharmacodynamic profiles (depending on project objectives) relative to the reference product are achieved.

Once similarity to the reference product is demonstrated, the manufacturing process is scaled-up to non-GMP pilot scale. In parallel, analytical methods are developed, in-process controls are established, and stability studies are performed.

The final deliverable includes the optimized synthetic route, the selected API solid form, and the drug product demonstrating in vivo similarity to the reference, together with comprehensive process and analytical transfer packages.

Initial pilot human studies are set to begin in Q3/2026. In early 2027, GMP certification will be secured for the Pilot Plant. This facility enables us to support the GMP manufacturing of the clinical trial batches and early human studies, providing an integrated development pathway from early-stage research, solid form design, and process development through clinical data generation in humans.

We provide the GMP batch certification and product release, including all associated QP and QA activities.

We provide comprehensive documentation support for regulatory submission, including ASMF preparation and full dossier compilation, covering GMP documentation writing and deficiency letters support.

Drug product development

Drug product development roadmap

Testimonials

Real stories from our partners in the lab and in business.

Scientific teams & startups

Samira Kaissi

Business director from Nanocomp

My advice to every startup founder is to get out of your own head and find a partner that can illuminate the blind spots.

API manufacturers

Alexandru Valea

CEO from Alcarta development

This gave the project legitimacy to sustain that it has demonstrated the technology is relevant in an environment that closely mimics the anticipated real-world application.

Drug product developers

PRO.MED.CS

Kapaji, in collaboration with MUNI PHARM Brno, provided tailored formulation solutions that met our exact needs.

Established pharmaceutical companies

Diederik Troost

European director of quality assurance from Glenmark Pharmaceuticals

Kapaji has provided a vital contribution with their technical knowledge, troubleshooting skills, and the development of a new method.

Scientific teams & startups

Ole Wiborg

CEO from Zerion

Kapaji provided us with an excellent analysis and valuable recommendations for further product development, considering both competitive target profiles, the market potential.

API manufacturers

Dr. Gordana Gadanji

Custom synthesis & technology transfer director from Midas

Midas Pharma GmbH entrusted Scale Up Laboratory s.r.o. with pharmaceutical development phase projects and was highly satisfied with the quality, reliability, and professionalism of the services provided.

About

Four specialised centres. One experienced team.

Kapaji

Kapaji is a Prague-based pharmaceutical development centre combining deep industrial expertise with analytical and formulation laboratories. We specialise in API solid-state selection, reverse engineering, small-scale drug product development, and the execution of pilot clinical studies, helping our partners turn complex pharmaceutical challenges into practical, development-ready solutions.

Scale Up Laboratory

Scale Up Laboratory is a chemical-pharmaceutical company offering research and development services for APIs (human and veterinary), intermediates, impurities, and specialty chemicals. Our well-experienced synthetic and analytics team develops cost-effective, scalable, and patent non-infringing innovative routes of syntheses in its own laboratories and the kilo-lab.

Veterinary Research Institute

The Veterinary Research Institute is a leading facility focused on the preclinical evaluation of developed drug product prototypes. We conduct preclinical studies, with a primary focus on pharmacokinetic and pharmacodynamic assessments. We offer advanced analytical capabilities for the sensitive quantification of active substance levels in biosamples. We provide clients with end-to-end study execution – from study design to interpretation, enabling faster and more confident decision-making in the next stages of development.

MUNI Pharm

With its small-scale GMP certified manufacturing site, MUNI Pharm is a cutting-edge facility, designed to bridge the gap between excellent research and industrial application. We specialise in the development and GMP certified manufacturing and evaluation of small-batch solid, liquid, and sterile drug forms, providing researchers and commercial partners with flexible, high-quality solutions for clinical evaluation and transfer to field application.

Success catalysts

One team, start to finish. Senior experts leading your project, identifying risks early, and keeping everything on track.

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